A Crew Cab version of the C/K 2500 was added to the Chevrolet heavy-duty pickup truck line-up in 1999. Offered only as a Fleetside box design with a 6.5-foot long bed, the C/K 2500 Crew Cab featured several mechanical enhancements over a 1500 Crew Cab allowing it to operate better on worksites. Available propulsion for the 1999 C/K 2500 Crew Cab line-up was furnished by a trio of eight-cylinder engines consisting of two gasoline Vortec powerplants as well as a diesel option.
Standard power came from the 255-horsepower 5.7-liter gasoline-fueled V-8. A more potent 290 horsepower 7.4-liter V-8 was the second choice offered to gasoline heavy-duty truck buyers. For abundant low-end torque, the 6.5-liter turbocharged diesel engine allowed up to 430 pound-feet of torque to the drive wheels of the Chevrolet Crew Cab truck. The diesel model of the C/K 2500 Crew Cab was discontinued after the 1999 model year. The engines of the Chevrolet Crew Cab can be paired up with a five-speed manual or a four-speed automatic transmission.
The Chevrolet C/K 2500 Crew Cab could receive engine power through either a rear-wheel or four-wheel drivetrain. Maximum towing capacity for the Chevrolet C/K 2500 Crew Cab was rated at 10,000 pounds when using a conventional ball hitch. Four-wheel disc brakes with anti-lock braking system were standard on the Chevrolet C/K 2500 Crew Cab allowing safe and consistent stops. While the truck is designed to be formidable force on the worksite, the four-door cabin can provide roomy and comfortable accommodations for up to six passengers. The Chevrolet C/K 2500 Crew Cab could also be equipped with comfort-oriented features such as air conditioning and leather seating. After 2000, the C/K 2500 Crew Cab was replaced by a three-quarter ton crew cab based on the Chevrolet Silverado heavy-duty pickup truck.